মঙ্গলবার, ২ এপ্রিল, ২০১৩

Chris Brown: 'I can't make everybody like me'

By Randee Dawn, TODAY contributor

Chris Brown is one of the more polarizing celebrities today: Ever since his conviction on felony assault charges in 2009 for attacking singer Rihanna, he's been on the downside of a lot of bad press and bad feelings from fans and critics alike. But in recent weeks, the R&B star has been mixing his promotional appearances for his new album "X" and single "Fine China" with a personal rehabilitation tour where he's opened up about the abuse and about the way he's changed since the incident. Brown sat down with TODAY's Matt Lauer on Monday to talk about the new music, and the new him.

"I've been humbled by the whole experience," he said. "From me losing everything, you know, to me having to regain public opinion or whatever it is -- but most importantly, you know, knowing that what I did was totally wrong and having to kind of deal with myself and kind of forgive myself in the same breath and being able to apologize to, you know, Rihanna and be that man that can be who is a man, you know?"

Still, Lauer noted that not all of Brown's behavior seems to indicate serious change, and he wondered what the singer thought of his continued skeptics. "I think everybody is entitled to their opinion. For me, it's just a learning process. You know, I have to just take it one day at a time. I can't make everybody like me ... it's about me being positive."

Lauer pointedly asked if Brown and Rihanna had reconciled as a couple, and Brown nodded: "Yeah, everything's good, we're fine." He also talked about how he had done 52 weeks of domestic violence counseling, to understand "Why did I do what I did?"

"I think it's just me proving myself once again," he said. "Knowing that what I did was wrong, and never doing it again. So as far as me and (Rihanna) are concerned, she knows my heart, and I know her heart. So I'm not really focused on the negative."

And in the end, he says, what's important to him is pleasing the important people in his life -- and not the critics. "For me, it's about proving myself to my fans," he said. "The only thing I can do is please my family, myself, and please her, you know, and my fans."

"X" is slated for release in August.

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Source: http://todayentertainment.today.com/_news/2013/04/01/17551265-chris-brown-talks-new-album-rehabbing-reputation-i-cant-make-everybody-like-me?lite

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Eye drops reduce signs of macular degeneration in mice

Targeting cholesterol in retina stops rogue blood vessel growth often seen in the vision disease

Targeting cholesterol in retina stops rogue blood vessel growth often seen in the vision disease

By Tina Hesman Saey

Web edition: April 2, 2013

Enlarge

EYE VIEW

Yellow deposits called drusen clutter the retina of a patient with macular degeneration. A new study suggests cholesterol, a component of drusen, may bloat aging immune cells, keeping them from fighting off blood vessels that invade the eye in the later stages of the disease.

Credit: Courtesy of R. Apte

Cholesterol-lowering eye drops may one day help preserve sight in people with a common cause of age-related vision loss, a new study suggests.

In old mice, eye drops that stimulate cells to shed cholesterol rejuvenated immune cells to fight off blood vessels encroaching into the retina, a hallmark of advanced age-related macular degeneration. The finding suggests that cholesterol buildup in the eye helps promote the condition, a leading cause of vision loss in people 50 and older.

Macular degeneration comes in two forms, dry and wet. In the dry, early stage of the disease, cells in the center of the retina die, blurring vision. This stage is often characterized by yellow clumps of lipids, including cholesterol, in the retina. These deposits can be a warning sign that a person is at risk of developing the wet form of the disease, in which blood vessels invade the back of the eye and leak, killing retinal cells. Patients are left with a hole in the middle of their field of vision.

In previous research, Rajendra Apte of the Washington University School of Medicine in St. Louis and colleagues showed that immune cells called macrophages are involved in macular degeneration. His team found that macrophages protect vision by halting blood vessels creeping into the eye. But the researchers also discovered that aging macrophages become bloated with cholesterol and can?t stop blood vessel invasion.

For the new study, published April 2 in Cell Metabolism, Apte?s team collected macrophages from young and old mice and people. Then the researchers counted the number of proteins that pump cholesterol, called ABC transporters, on the cells. Old macrophages had fewer pumps than young cells did. The old cells, particularly those with lower numbers of a cholesterol pump called ABCA1, couldn?t combat blood vessel growth as well as the young ones could.

The team traced the diminished cholesterol-pumping ability to a small piece of genetic material called a microRNA. The microRNA miR-33 builds up as cells age, the researchers discovered. Because this piece of RNA puts the brakes on production of the ABCA1 pump, the result is that macrophages can?t jettison cholesterol the way they once did.

Blocking miR-33 or using drugs that stimulate other cholesterol-shedding mechanisms could restore macrophages? ability to fend off blood vessel proliferation, Apte?s team found. Mice given injections of either the microRNA blocker or the drugs had fewer encroaching blood vessels in their eyes than placebo-treated animals did. And eye drops that stimulate cells in the eye to dump cholesterol ?worked as well as the injections, the researchers found. That could mean that doctors could treat just people?s eyes, potentially avoiding side effects that might accompany whole-body therapies.

Apte?s group has shown that cholesterol is a player, particularly in the ?wet? form of macular degeneration, says Anand Swaroop, a geneticist who studies eye diseases at the National Eye Institute in Bethesda, Md. But Swaroop doubts it is the underlying cause of the disease. Genetic studies indicate that how well cells dump cholesterol is just one of many factors that add up to produce macular degeneration, he says.

A treatment based on lowering cholesterol in the eye is still years and many tests of safety and efficacy away, Swaroop says, but adds that he?d be delighted if eye drops could stop the disease. Wet macular generation is often treated with monthly injections of drugs that inhibit blood vessel growth. ?When you?re 80 years old,? he says ?you don?t want to be pricked in the eye every month.?

Source: http://www.sciencenews.org/view/generic/id/349307/title/Eye_drops_reduce_signs_of_macular_degeneration_in_mice

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সোমবার, ১ এপ্রিল, ২০১৩

Consumer Electronics Daily News: IEEE Computer Society to Host ...

The fourth annual Software Experts Summit, "Smart Data Science: Harnessing Data for Intelligent Decision-Making," will be held on?July 17?at Microsoft in?Redmond, Washington, and feature leading experts from around the world.

Sponsored by IEEE Computer Society and?IEEE Software?magazine,?the one-day SES13 will provide organizations with solid advice on making intelligent decisions about handling today's increasing volume and array of data.

"Companies and research institutes are facing a deluge of data--2.5 quintillion bytes per day, by IBM's estimate. In this environment, organizations need to learn to be smart about data?exploring analytics and new techniques to deal with the volume and diversity of data," said?Forrest Shull, a Division Director at Fraunhofer Center for Experimental Software Engineering and editor in chief of?IEEE Software. "SES13 will give attendees exposure to the latest ideas and strategies on Smart Data Science from experts in both academia and private industry."

Registration is now open. The early-bird deadline is?June 1. To register, visit?www.computer.org/ses13.

Among the speakers from industry and academia will be?Ayse Bener?from?Ryerson University,?Wolfram Schulte?from Microsoft Research, Shull,?James Whittaker?from Microsoft, and?Paul Zikopoulos?from IBM. SES 2013 will take place at the Microsoft Conference Center, located on the main Microsoft Headquarters Campus in?Redmond.

The event will help organizations:

  • use even small sets of data to guide decision making due to inconsistent data structures,
  • analyze different types of data, such as text messages, multimedia presentations, and video streams,
  • effectively use technologies that create and manage data.

Source: http://www.cedailynews.com/2013/04/ieee-computer-society-to-host-fourth-annual-software-experts-summit-on-july-17.html

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AP IMPACT: Cartels dispatch agents deep inside US

In this Feb. 14, 2013 photo, Art Bilek, executive vice president of the Chicago Crime Commission, left, announces that Joaquin ``El Chapo'' Guzman, a drug kingpin in Mexico, has been named Chicago's Public Enemy No. 1, during a news conference in Chicago. Looking on is Jack Riley, right, head of the Drug Enforcement Administration in Chicago and Peter Bensinger, former Administrator of the United States DEA. Ruthless drug cartels have long been the nation?s No. 1 supplier of illegal drugs, but in the past, their operatives rarely ventured beyond the border. A wide-ranging Associated Press review of federal court cases and government drug-enforcement data, plus interviews with many top law enforcement officials, indicate the groups have begun deploying agents from their inner circles to the U.S. (AP Photo/M. Spencer Green)

In this Feb. 14, 2013 photo, Art Bilek, executive vice president of the Chicago Crime Commission, left, announces that Joaquin ``El Chapo'' Guzman, a drug kingpin in Mexico, has been named Chicago's Public Enemy No. 1, during a news conference in Chicago. Looking on is Jack Riley, right, head of the Drug Enforcement Administration in Chicago and Peter Bensinger, former Administrator of the United States DEA. Ruthless drug cartels have long been the nation?s No. 1 supplier of illegal drugs, but in the past, their operatives rarely ventured beyond the border. A wide-ranging Associated Press review of federal court cases and government drug-enforcement data, plus interviews with many top law enforcement officials, indicate the groups have begun deploying agents from their inner circles to the U.S. (AP Photo/M. Spencer Green)

In this Dec. 11, 2012 file photo, Jack Riley, head of the Drug Enforcement Administration in Chicago, points out local Mexican drug cartel problem areas on a map in the new interagency Strike Force office in Chicago. Looking on is DEA agent Vince Balbo. The ruthless syndicates have long been the nation?s No. 1 supplier of illegal drugs, but in the past, their operatives rarely ventured beyond the border. A wide-ranging Associated Press review of federal court cases and government drug-enforcement data, plus interviews with many top law enforcement officials, indicate the groups have begun deploying agents from their inner circles to the U.S. (AP Photo/M. Spencer Green, File)

This 2009 photo provided by the Gwinnett County Sheriff's Department in Lawrenceville, Ga., shows reputed cartel operative Socorro Hernandez-Rodriguez after his arrest in a suburb of Atlanta. Hernandez-Rodriguez was later convicted of sweeping drug trafficking charges. Prosecutors said he was a high-ranking figure in the La Familia cartel, sent to the U.S. to run a drug cell. His defense lawyers denied he was a major figure in the cartel. (AP Photo/Courtesy of the Gwinnett County Sheriff?s Department)

This photo dated in 2007 from federal court documents provided by attorneys for Jose Gonzales-Zavala shows Gonzales-Zavala with two of his children allegedly taken in Mexico. Prosecutors say Gonzales-Zavala was a member of the La Familia cartel, based in southwestern Mexico, and dispatched to the Chicago area to oversee one of the cartel's lucrative trafficking cells. His defense team entered the photograph into evidence during the sentence stage of his case in arguing for leniency. In 2011, he was sentenced to 40 years in prison by a federal judge in Chicago. (AP Photo/Attorneys for Jose Gonzales-Zavala)

FILE - In this Oct. 22, 2009 file photo, weapons and drugs seized in special joint operation conducted with the Drug Enforecement Administration against the La Familia drug cartel based out of Michoacan, Mexico and operating in San Bernardino and surrounding counties, are on display at a news conference at sheriff's headquarters in San Bernardino, Calif. Drug cartels have long been the nation?s No. 1 supplier of illegal drugs, but in the past, their operatives rarely ventured beyond the border. A wide-ranging Associated Press review of federal court cases and government drug-enforcement data, plus interviews with many top law enforcement officials, indicate the groups have begun deploying agents from their inner circles to the U.S. (AP Photo/Reed Saxon, File)

(AP) ? Mexican drug cartels whose operatives once rarely ventured beyond the U.S. border are dispatching some of their most trusted agents to live and work deep inside the United States ? an emboldened presence that experts believe is meant to tighten their grip on the world's most lucrative narcotics market and maximize profits.

If left unchecked, authorities say, the cartels' move into the American interior could render the syndicates harder than ever to dislodge and pave the way for them to expand into other criminal enterprises such as prostitution, kidnapping-and-extortion rackets and money laundering.

Cartel activity in the U.S. is certainly not new. Starting in the 1990s, the ruthless syndicates became the nation's No. 1 supplier of illegal drugs, using unaffiliated middlemen to smuggle cocaine, marijuana and heroin beyond the border or even to grow pot here.

But a wide-ranging Associated Press review of federal court cases and government drug-enforcement data, plus interviews with many top law enforcement officials, indicate the groups have begun deploying agents from their inner circles to the U.S. Cartel operatives are suspected of running drug-distribution networks in at least nine non-border states, often in middle-class suburbs in the Midwest, South and Northeast.

"It's probably the most serious threat the United States has faced from organized crime," said Jack Riley, head of the Drug Enforcement Administration's Chicago office.

The cartel threat looms so large that one of Mexico's most notorious drug kingpins ? a man who has never set foot in Chicago ? was recently named the city's Public Enemy No. 1, the same notorious label once assigned to Al Capone.

The Chicago Crime Commission, a non-government agency that tracks crime trends in the region, said it considers Joaquin "El Chapo" Guzman even more menacing than Capone because Guzman leads the deadly Sinaloa cartel, which supplies most of the narcotics sold in Chicago and in many cities across the U.S.

Years ago, Mexico faced the same problem ? of then-nascent cartels expanding their power ? "and didn't nip the problem in the bud," said Jack Killorin, head of an anti-trafficking program in Atlanta for the Office of National Drug Control Policy. "And see where they are now."

Riley sounds a similar alarm: "People think, 'The border's 1,700 miles away. This isn't our problem.' Well, it is. These days, we operate as if Chicago is on the border."

Border states from Texas to California have long grappled with a cartel presence. But cases involving cartel members have now emerged in the suburbs of Chicago and Atlanta, as well as Columbus, Ohio, Louisville, Ky., and rural North Carolina. Suspects have also surfaced in Indiana, Michigan, Minnesota and Pennsylvania.

Mexican drug cartels "are taking over our neighborhoods," Pennsylvania Attorney General Kathleen Kane warned a legislative committee in February. State Police Commissioner Frank Noonan disputed her claim, saying cartels are primarily drug suppliers, not the ones trafficking drugs on the ground.

For years, cartels were more inclined to make deals in Mexico with American traffickers, who would then handle transportation to and distribution within major cities, said Art Bilek, a former organized crime investigator who is now executive vice president of the crime commission.

As their organizations grew more sophisticated, the cartels began scheming to keep more profits for themselves. So leaders sought to cut out middlemen and assume more direct control, pushing aside American traffickers, he said.

Beginning two or three years ago, authorities noticed that cartels were putting "deputies on the ground here," Bilek said. "Chicago became such a massive market ... it was critical that they had firm control."

To help fight the syndicates, Chicago recently opened a first-of-its-kind facility at a secret location where 70 federal agents work side-by-side with police and prosecutors. Their primary focus is the point of contact between suburban-based cartel operatives and city street gangs who act as retail salesmen. That is when both sides are most vulnerable to detection, when they are most likely to meet in the open or use cellphones that can be wiretapped.

Others are skeptical about claims cartels are expanding their presence, saying law-enforcement agencies are prone to exaggerating threats to justify bigger budgets.

David Shirk, of the University of San Diego's Trans-Border Institute, said there is a dearth of reliable intelligence that cartels are dispatching operatives from Mexico on a large scale.

"We know astonishingly little about the structure and dynamics of cartels north of the border," Shirk said. "We need to be very cautious about the assumptions we make."

Statistics from the DEA suggest a heightened cartel presence in more U.S. cities. In 2008, around 230 American communities reported some level of cartel presence. That number climbed to more than 1,200 in 2011, the most recent year for which information is available, though the increase is partly due to better reporting.

Federal agents and local police say they have become more adept at identifying cartel members or operatives using wiretapped conversations, informants or confessions. Hundreds of court documents reviewed by the AP appear to support those statements.

"This is the first time we've been seeing it ? cartels who have their operatives actually sent here," said Richard Pearson, a lieutenant with the Louisville Metropolitan Police Department, which arrested four alleged operatives of the Zetas cartel in November in the suburb of Okolona.

People who live on the tree-lined street where authorities seized more than 2,400 pounds of marijuana and more than $1 million in cash were shocked to learn their low-key neighbors were accused of working for one of Mexico's most violent drug syndicates, Pearson said.

One of the best documented cases is Jose Gonzalez-Zavala, who was dispatched to the U.S. by the La Familia cartel, according to court filings.

In 2008, the former taxi driver and father of five moved into a spacious home at 1416 Brookfield Drive in a middle-class neighborhood of Joliet, southwest of Chicago. From there, court papers indicate, he oversaw wholesale shipments of cocaine in Illinois, Wisconsin and Indiana.

Wiretap transcripts reveal he called an unidentified cartel boss in Mexico almost every day, displaying the deference any midlevel executive might show to someone higher up the corporate ladder. Once he stammered as he explained that one customer would not pay a debt until after a trip.

"No," snaps the boss. "What we need is for him to pay."

The same cartel assigned Jorge Guadalupe Ayala-German to guard a Chicago-area stash house for $300 a week, plus a promised $35,000 lump-sum payment once he returned to Mexico after a year or two, according to court documents.

Ayala-German brought his wife and child to help give the house the appearance of an ordinary family residence. But he was arrested before he could return home and pleaded guilty to multiple trafficking charges. He will be sentenced later this year.

Socorro Hernandez-Rodriguez was convicted in 2011 of heading a massive drug operation in suburban Atlanta's Gwinnett County. The chief prosecutor said he and his associates were high-ranking figures in the La Familia cartel ? an allegation defense lawyers denied.

And at the end of February outside Columbus, Ohio, authorities arrested 34-year-old Isaac Eli Perez Neri, who allegedly told investigators he was a debt collector for the Sinaloa cartel.

An Atlanta attorney who has represented reputed cartel members says authorities sometimes overstate the threat such men pose.

"Often, you have a kid whose first time leaving Mexico is sleeping on a mattress at a stash house playing Game Boy, eating Burger King, just checking drugs or money in and out," said Bruce Harvey. "Then he's arrested and gets a gargantuan sentence. It's sad."

Typically, cartel operatives are not U.S. citizens and make no attempt to acquire visas, choosing instead to sneak across the border. They are so accustomed to slipping back and forth between the two countries that they regularly return home for family weddings and holidays, Riley said.

Because cartels accumulate houses full of cash, they run the constant risk associates will skim off the top. That points to the main reason cartels prefer their own people: Trust is hard to come by in their cutthroat world. There's also a fear factor. Cartels can exert more control on their operatives than on middlemen, often by threatening to torture or kill loved ones back home.

Danny Porter, chief prosecutor in Gwinnett County, Ga., said he has tried to entice dozens of suspected cartel members to cooperate with American authorities. Nearly all declined. Some laughed in his face.

"They say, 'We are more scared of them (the cartels) than we are of you. We talk and they'll boil our family in acid,'" Porter said. "Their families are essentially hostages."

Citing the safety of his own family, Gonzalez-Zavala declined to cooperate with authorities in exchange for years being shaved off his 40-year sentence.

In other cases, cartel brass send their own family members to the U.S.

"They're sometimes married or related to people in the cartels," Porter said. "They don't hire casual labor." So meticulous have cartels become that some even have operatives fill out job applications before being dispatched to the U.S., Riley added.

In Mexico, the cartels are known for a staggering number of killings ? more than 50,000, according to one tally. Beheadings are sometimes a signature.

So far, cartels don't appear to be directly responsible for large numbers of slayings in the United States, though the Texas Department of Public Safety reported 22 killings and five kidnappings in Texas at the hands of Mexican cartels from 2010 through mid- 2011.

Still, police worry that increased cartel activity could fuel heightened violence.

In Chicago, the police commander who oversees narcotics investigations, James O'Grady, said street-gang disputes over turf account for most of the city's uptick in murders last year, when slayings topped 500 for the first time since 2008. Although the cartels aren't dictating the territorial wars, they are the source of drugs.

Riley's assessment is stark: He argues that the cartels should be seen as an underlying cause of Chicago's disturbingly high murder rate.

"They are the puppeteers," he said. "Maybe the shooter didn't know and maybe the victim didn't know that. But if you follow it down the line, the cartels are ultimately responsible."

___

Follow Michael Tarm at www.twitter.com/mtarm .

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-01-Cartels-Coming%20to%20America/id-c5632c7893744bd1931ed864dc864b32

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Respecting people's rules with their pets - Cat Forum : Cat ...

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Source: http://www.catforum.com/forum/47-lounge/180537-respecting-peoples-rules-their-pets.html

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রবিবার, ৩১ মার্চ, ২০১৩

Giant panda artificially inseminated at U.S. National Zoo

WASHINGTON (Reuters) - Veterinarians at the National Zoo artificially inseminated the zoo's female giant panda Mei Xiang on Saturday after natural breeding failed to occur, zoo keepers said.

Mei Xiang was put under general anesthesia and inseminated with a combination of fresh semen and frozen semen collected from the zoo's male giant panda Tian Tian. The scientists said they planned a second insemination later on Saturday.

Veterinarians detected a rise in hormone levels on Tuesday, indicating Mei Xiang was ready to breed but said "no competent breeding" between the panda pair had occurred.

"We are hopeful that our breeding efforts will be successful this year, and we're encouraged by all the behaviors and hormonal data we've seen so far," said Dave Wildt, head of the Center for Species Survival at the Smithsonian Conservation Biology Institute.

Scientists will continue to monitor Mei Xiang's hormone levels in the coming months and conduct ultrasounds to determine whether she is pregnant. A pregnancy lasts between 95 and 160 days, they said.

Mei Xiang has given birth to two cubs. One died a week after its birth last year. The other was born in 2005 and is now at the China Conservation and Research Center for the Giant Panda in Wolong.

(Reporting by Jane Sutton; editing by Jackie Frank)

Source: http://news.yahoo.com/giant-panda-artificially-inseminated-u-national-zoo-173415545.html

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Astronaut Celebrates Easter in Space (Easter Eggs, Included)

Children around the world aren't the only ones having an Easter egg hunt today. Astronauts in space will get Easter treats, too.

Canadian astronaut Chris Hadfield, who commands the International Space Station, made sure that the Easter Bunny would make a special trip to the orbital lab today (March 31) just in time for an Easter celebration in space.

"Good Morning, Earth! A fine Easter Sunday morning to you from the crew of the International Space Station," Hadfield wrote in a post on Twitter, where he is chronicling his mission under the name @Cmdr_Hadfield.

Hadfield snapped a sunrise photo of Earth on Easter showing the sun glinting off the Great Lakes in North America this morning to mark the occasion. Then he revealed his Easter secret.

"Don't tell my crew, but I brought them Easter Eggs :)," Hadfield wrote as he posted a photo of his space Easter treats. [Astronaut Chris Hadfield's Amazing Space Photos]

In the photo, six large plastic Easter eggs ? each a different color ?float inside a plastic bag while Hadfield presses a finger to his lips in a "Shh" gesture.

Easter Sunday is a day off for the space station crew because it falls on a weekend. Hadfield is Canada's first commander of the station and took charge of the orbiting laboratory earlier in March.

Hadfield's Expedition 35 crew includes himself, two Americans and three Russians. Three crewmembers, American astronaut Chris Cassidy and Russian cosmonauts Pavel Vinogradov and Alexander Misurkin, just arrived at the station on Thursday (March 28).

Astronauts in space have a long tradition of spending holidays in space dating back decades to the early days of human spaceflight, when NASA astronauts celebrated Christmas orbiting the moon during the 1968 Apollo 8 mission.

Christmas, Thanksgiving, New Year's Day and other traditional holidays from Russia and other space station partner countries have been celebrated in space since the first crew took up residence in the orbiting laboratory in 2000. The space station has been manned by rotating crews ever since.

Hadfield has shown a dedication to marking holidays off the planet. In March, he donned a green shirt and bowtie for St. Patrick's Day, and in February he wore a heart headband for Valentine's Day and a funny hat and necklace for Mardi Gras.

Hadfield and two Expedition 35 crewmates ? NASA astronaut Tom Marshburn and Russian cosmonaut Roman Romanenko ? are due to return to Earth in May. They have been living on the space station in since mid-December.

Email Tariq Malik at tmalik@space.com or follow him @tariqjmalikand Google+. Follow us @Spacedotcom, Facebookand Google+. Original article on SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/astronaut-celebrates-easter-space-easter-eggs-included-151008296.html

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