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বৃহস্পতিবার, ৪ এপ্রিল, ২০১৩

Google and Asustek to release second generation Nexus 7 tablet in July, says Reuters

Google's next generation of Nexus 7 tablets from Asus will be Qualcomm-powered and arrive this July, according to Reuters. If its sources are to be believed, Mountain View is aiming to ship eight million units by the end of the year, showing it has a lot of confidence in the upcoming model. Other leaked info shows it to have more screen resolution, a thinner bezel and an unspecified Qualcomm CPU instead of the current model's NVIDIA Tegra 3, possibly to save power. There's no info on pricing or other specs and Google's not speaking at this point, of course -- but if it proves accurate, hopefully the two companies have learned their lesson from the current model's runaway success and will ramp production accordingly.

Filed under: Tablets, ASUS, Google

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Source: Reuters

Source: http://www.engadget.com/2013/04/03/reuters-google-and-asustek-to-release-second-generation-nexus-7/

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Fairchild visits campus, shares poetry

Poet B.H. Fairchild doesn?t think he sees the world differently. He does, however, see language differently.

?I think there?s something that happens for both writers and obsessive readers,? he said. ?It?s a kind of romance wherein you fall in love with language. They are the sort of people who will find themselves reading the same sentence over and over even though they understand the meaning.?

Fairchild visited campus April 2 and 3 to share his writing with students and faculty alike. He read from his poetry on Tuesday night and gave a lecture titled ?Coming into Poetry? on Wednesday night.

Fairchild is a professor at the University of North Texas. He has lived all over the lower Midwest, growing up in small towns in Texas, Oklahoma, and Kansas. He has written and published six books of poetry.

?His poems are about average people living average lives and his discovering in those lives of husbands and wives and laborers the stuff of serious art,? John Somerville, professor of English and director the visiting writers program, said.

Somerville first heard about Fairchild while reading a book by Dennis Donahue called ?Speaking of Beauty.?

?Early in the book he refers to a poem by B.H. Fairchild called ?Beauty,?? Somerville said. ?I went to find the poem. It had originally appeared in the Southern Review. I went to the basement in Mossey where they keep the back copies and found ?Beauty.? I love that poem.?

In addition to poetry, Fairchild has written a book, ?Such Holy Song,? exploring the relationship between William Blake?s poetry and music.

?He composed melodies to ?The Song?s of Innocence and Experience? and would perform them,? Fairchild said. ?He was also influenced by oratorio.?

Fairchild has a colorful employment history prior to post-graduate work at the Claremont Graduate University, Texas Christian University, and the University of North Texas. Fairchild described working as a movie usher, a technical writer for a nitroglycerin plant, and an English tutor for the Kansas Basketball team.

?I was paid 45 cents an hour for ushering, and 75 cents an hour for changing the marquee,? he said.

Fairchild also said he thinks this experience, in addition to general life experience, contributed to his profession as a writer.

?I don?t think poetry is solely an act of the imagination,? he said.

?There?s a fair amount of poetry to me that leans too far to the abstract,? Somerville said. ?And certainly he writes about ideas, but they are embodied in a world that?s recognizable to the average person.?

Somerville pointed to Fairchild?s poem about the crucifixion, ?The Deposition,? as an example.

?It?s not average, but it is so incarnate, it?s all in the flesh?a real figure hanging on a cross,? he said.

Fairchild said he thinks the crucifixion is not often thought about in it?s total reality and he wanted to show the event as it would probably be?sweaty, smelly, and filthy.

?If you are going to finally write a poem about the crucifixion you owe it to yourself to be as true and real as you possibly can,? he said.

Twice in ?The Deposition? Fairchild describes the eyes of Christ?once as open, once as being shut by the narrator. Each instance is followed by the phrase ?I know who you are.?

?The finite mind can never truly know itself,? Fairchild explained. ?Only an infinite mind can truly comprehend your mind.?

Fairchild read other selected poems Tuesday night, including ?Beauty? and ?The Left-Fielder?s Sestina,? a poem he published online.

?I?ve written two sestina?s in my life,? he said. ?The one I wrote in one day. I?ve been working on ?The Left-Fielder?s Sestina? on and off for almost six years.?

For Fairchild, the writing process is a thing of quiet, concentration and time.

?I have written in the midst of commotion, but I really prefer to be completely in solitude,? he said. ?I have to have long periods of concentration.?

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? awood@hillsdale.edu (57)

Source: http://www.hillsdalecollegian.com/2013/04/fairchild-visits-campus-shares-poetry/

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বুধবার, ৩ এপ্রিল, ২০১৩

US missile defense shield to counter NKorea threat

Defense Secretary Chuck Hagel speaks at the National Defense University at Fort McNair in Washington, Wednesday, April 3, 2013. Hagel warned of sharply deeper cuts to personnel, health care and weapons systems across his department, in order to put the brakes on spiraling costs and reshape the military for leaner budgets and new challenges. (AP Photo/Manuel Balce Ceneta)

WASHINGTON (AP) ? The Pentagon said Wednesday it was deploying a missile defense shield to Guam to protect the U.S. and its allies in the region in response to increasingly hostile rhetoric from North Korea. The North renewed its threat to launch a nuclear attack on the United States.

The threat issued by the General Staff of the Korean People's Army capped a week of psychological warfare and military muscle moves by both sides that have rattled the region.

On Wednesday, the Pentagon announced it will deploy a land-based, high-altitude missile defense system to Guam to strengthen the Asia-Pacific region's protections against a possible attack.

Pyongyang, for its part, said that America's ever-escalating hostile policy toward North Korea "will be smashed" by the North's nuclear strike and the "merciless operation" of its armed forces.

"The U.S. had better ponder over the prevailing grave situation," said the translated statement, which was issued before the Pentagon announced plans to send a missile defense shield to Guam.

The Pentagon had no immediate reaction to the latest statement, but earlier Wednesday Defense Secretary Chuck Hagel labeled North Korea's rhetoric as a real, clear danger and threat to the U.S. and its Asia-Pacific allies. And he said the U.S. is doing all it can to defuse the situation, echoing comments a day earlier by Secretary of State John Kerry.

"Some of the actions they've taken over the last few weeks present a real and clear danger and threat to the interests, certainly of our allies, starting with South Korea and Japan and also the threats that the North Koreans have leveled directly at the United States regarding our base in Guam, threatened Hawaii, threatened the West Coast of the United States," Hagel said.

He said he believes that the U.S. has had a "measured, responsible, serious responses to those threats."

Deployment of the Terminal High Altitude Area Defense System is the latest step the U.S. has taken to bolster forces in the region in a far-reaching show of force aimed at countering the North Korean threat.

In recent months, North Korea has taken a series of actions Washington deemed provocative, including an underground nuclear test in February and a rocket launch in December that put a satellite into space and demonstrated mastery of some of the technologies needed to produce a long-range nuclear missile. Then, several weeks ago, the North threatened to pre-emptively attack the U.S.

In response, the Pentagon announced it would enhance missile defenses based on the U.S. West Coast, and it highlighted the deployment of B-52 and B-2 bombers, as well as two F-22 stealth fighters, to South Korea as part of an annual military exercise.

As the exchange of rhetoric grew, U.S. officials this week said the Navy would keep the USS Decatur, a destroyer armed with missile defense systems, near the Korean peninsula for an unspecified period of time. Another destroyer, the USS John S. McCain, was shifted to the waters off the southwest coast of the Korean peninsula.

Tensions have flared many times in the six decades since a truce halted the 1950-53 Korean War, but the stakes are higher now that a defiant North Korea appears to have moved closer to building a nuclear bomb that could not only threaten the South and other U.S. allies in Asia but possibly, one day, even reach U.S. territory.

Even without nuclear arms, the communist North poses enough artillery within range of Seoul to devastate large parts of the capital before U.S. and South Korea could fully respond. The U.S. has about 28,500 troops in the South, and it could call on an array of air, ground and naval forces to reinforce the peninsula from elsewhere in Asia and the Pacific.

U.S. officials have said that the Pentagon's military response to Pyongyang's threats has so far been aimed more at assuring South Korea and other allies in the region that America is committed to their security. U.S. military leaders also have said that despite the escalating rhetoric, they have seen nothing to suggest that North Korea is making any military moves to back up its threats.

Hagel told an audience at the National Defense University that there is a path to peace on the troubled Korean peninsula, but it doesn't include making nuclear threats or taking provocative actions.

The land-based THAAD missile defense system includes a truck-mounted launcher, tracking radar, interceptor missiles, and an integrated fire control system. The Pentagon said the system will boost defenses for American citizens in Guam, a U.S. territory, and U.S. forces stationed there.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-03-US-Hagel-Korea/id-bf3260f79c8a49cc91a1a22c8188a475

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Penguins captain Sidney Crosby out of hospital

PITTSBURGH (AP) ? Pittsburgh Penguins captain Sidney Crosby is out of the hospital after breaking his jaw Saturday.

The Penguins confirmed on their Twitter account Tuesday that Crosby had been released a day earlier. He will be out of the lineup indefinitely after undergoing surgery.

Crosby was hurt in the first period of the Penguins' 2-0 win over the New York Islanders when he was struck in the mouth by a puck from a deflected shot.

The Eastern Conference-leading Penguins, with 15 straight wins, play their first game without Crosby on Tuesday night at home against Buffalo.

Source: http://news.yahoo.com/penguins-captain-sidney-crosby-hospital-175653307--nhl.html

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Mechanism of mutant histone protein in childhood brain cancer revealed

Tuesday, April 2, 2013

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy.

Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome sequencing consortiums that directly links a mutated histone protein to a rare brain stem cancer in children called DIPG. Collectively, these studies represented the first time scientists had linked a histone mutation to a disease, and piqued the interest of Peter Lewis, a research associate in Allis' Laboratory of Chromatin Biology and Epigenetics, who spearheaded these new studies.

Together with DNA, histones comprise the gene packaging material called chromatin. The mutation occurs on histone H3, and involves the remarkably specific substitution of one amino acid, lysine, for another, methionine, at a key position on the histone's tail, "silencing" the associated gene. Normally, gene silencing arises when an enzyme called a methyltransferase, containing a structural region called the SET domain, attaches a methyl chemical group to the lysine at position 27 in the H3 tail. This highly specific chemical reaction, called methylation, is disrupted by the replacement of the lysine with methionine, which could result in gene mis-regulation.

Lewis and his colleagues looked at human DIPG tumors that contained the lysine-to-methionine substitution and determined that mutated histone H3 comprised anywhere from 3.6 percent to 17.6 percent of total H3 in DIPG samples. They also found a global reduction in the levels of methylation of normal H3 histones when small amounts of the mutant H3 were added to normal human cells.

"I have often said, 'Every amino acid in histones matters,'" says Allis, who is the Joy and Jack Fishman Professor. "These studies underscore just how true that may be."

The researchers went on to demonstrate that the reduction in methylation of normal H3 histones results from interference with activity of a methyltransferase called PRC2 by the mutant histone. Methylation of normal H3 by PRC2 leads to repression of genes involved in cellular growth pathways. Without methylation, genes involved in these pathways likely become activated, promoting the growth of tumors in DIPG. Allis and Lewis received funding from the National Institutes of Health and the Starr Cancer Consortium. Key collaborators in this work included Oren Becher at Duke University Medical Center and Tom Muir at Princeton University and their colleagues.

"Our finding provides us with a useful tool for probing biological processes," says Lewis. "This also tells us how to inhibit enzymes, which could lead to the development of pharmaceuticals that mimic the action of these mutants."

"We now have a model for the promotion of brain stem cancers through aberrant epigenetic silencing through the inhibition of PRC2 by a mutant histone," says Allis. "We have uncovered a potentially useful mechanism to exclusively inhibit individual SET-domain methyltransferases, and conceivably other chromatin-modifying enzymes, implicated in a variety of malignancies."

###

Rockefeller University: http://www.rockefeller.edu

Thanks to Rockefeller University for this article.

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Source: http://www.labspaces.net/127548/Mechanism_of_mutant_histone_protein_in_childhood_brain_cancer_revealed

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মঙ্গলবার, ২ এপ্রিল, ২০১৩

Russia going back to Afghanistan? Kremlin confirms it could happen

Almost a quarter century after Soviet troops left Afghanistan in defeat, Russia may return to the country by establishing "maintenance bases" for Russian-made military equipment after NATO winds down its operations there next year, defense ministry officials have confirmed.

"It is important to maintain the weapon systems and military equipment of the Afghan armed forces in a serviceable state," Sergei Koshelev, head of the Russian defense ministry's international cooperation department, told journalists late last week.

Moscow is extremely worried "that any escalation of the situation in Afghanistan after NATO troops pull out in 2014 could have a negative impact on the security of both Russia and other European nations," he added.

RECOMMENDED: Do you know anything about Russia? A quiz.

Russian experts insist that it's not an attempt to overcome Russia's own version of the "Vietnam syndrome" ? an agonized folk memory of the decade-long war in Afghanistan that arguably brought down the Soviet Union. Rather, they say the new engagement will be limited to commercial obligations, negotiated with NATO before it pulls most of its forces out, and will absolutely not involve any active military role.

"Someone has to help the Afghan people build a peaceful life. They've known nothing but weapons and war for so long," says Oleg Tikhonov, deputy head of the Injured Afghan War Veterans in Sverdlovsk region, western Siberia.

"But Russia must never repeat its past mistakes. There cannot again be any Russian troops in Afghanistan. After the past, it would be impossible to explain why Russian boys are dying there. You cannot do such things without the people's consent," he adds.

TWOFOLD GOALS

Analysts say that, first, there is an objective need to maintain and repair generations of Soviet and Russian-made military hardware that constitute the main weaponry used by the Afghan security forces. Over the past decade, rather than re-equip Afghan government troops with sophisticated Western-made arms, the US has purchased hundreds of millions of dollars worth of Russian weapons, including helicopters, from Russia's state arms exporter Rosoboronexport to fill their needs.

Second, Russia wants to establish forward posts in Afghanistan because it is increasingly alarmed about a possible resurgence of the cross-border militant Islamist incursions that sowed chaos in the post-Soviet republics of Tajikistan and Uzbekistan during the turbulent 1990s. Production of narcotics has exploded under NATO's watch in Afghanistan, and much of it moves via criminal pipelines through former Soviet central Asia and Russia, feeding official corruption and the growth of mafia power throughout the region. Many Russians say they fear that the NATO withdrawal may soon leave them to face these challenges alone.

Over the past couple of years, Russia has become more active assisting the beleaguered NATO mission in Afghanistan, even granting the use of an important airbase in central Russia to help with resupply efforts. Russian leaders have repeatedly urged NATO not to leave in 2014, and to stay in Afghanistan until "the job is done."

But most Russian experts say they are now resigned to the US pulling the plug in 2014 and, in a pattern familiar from previous wars from Vietnam to Iraq, abandoning the region to its own devices.

"Look at Iraq. The US lost interest in it, and nobody cares if it's becoming engulfed in civil war," says Vadim Kozyulin, a researcher with the PIR Center, a leading Moscow security think tank.

"The same process may happen in Afghanistan, and could develop much more quickly. The US effort in Afghanistan is about to end. It's time for Russia to design a new effort, which means we have to take a share of responsibility on ourselves. We're already playing the role of political and military leader in central Asia.... Even though [President Vladimir] Putin previously said we won't send Russian specialists to Afghanistan, the Russian military now says we might create enterprises on Afghan territory to service military equipment. The situation is changing," he adds.

RUSSIA'S MILITARY-EQUIPMENT FOOTHOLD

The US has already purchased about 70 Russian Mi-17 helicopters for the Afghan army, at around $17 million apiece, and wants to buy 30 more ? an arrangement that's extremely controversial in the US.

"NATO buys Russian arms for the Afghan forces in part because they're very familiar with this equipment, and in part because they probably don't want to supply sophisticated Western arms that might wind up in the hands of the Taliban," says Fyodor Lukyanov, editor of Russia in Global Affairs, a leading Moscow foreign policy journal.

"As Russia tries to extend its economic presence, this edge in military equipment is about the only thing going for us. And it's guaranteed that Russia's own military-industrial lobbies will push hard for expanding it," he adds.

One of Mr. Putin's key policies is to knit together former Soviet lands in a new Eurasian Union that would be driven by economic synergies rather than political domination. As Russia pivots eastward, the resource-rich but politically unstable former Soviet republics of central Asia ? which abut Afghanistan ? are taking on a whole new significance.

Some experts say that stability in Afghanistan, with which the USSR maintained good relations for most of its history, will be key to Russia's ability to achieve its other goals in the region.

"Russia is returning to Afghanistan. Indeed, according to some information, Russia is already doing that without waiting for the Americans to leave," says Anatoly Tsyganok, an analyst with the independent Center for Military Forecasting and a member of the Russian Defense Ministry's advisory public council.

"I think we should be investing right now. There are many proposals from the Afghan government on the table, including participation in geological surveys, developing oil production and water resources. There is an offer to build a metro in Kabul, and it is being considered in Moscow.... Consider that the Chinese are already very active. They are building roads in Taliban-held territory, using the Taliban for protection. We need to look ahead, and be practical about it," he says.

Gen. Makhut Garayev, president of the Russian Academy of Military Sciences and a former adviser to the pro-Soviet regime of Mohammad Najibullah in Afghanistan, says Russia needs to step cautiously in any return to Afghanistan.

"There has been a lot of harm done to Afghanistan, and many countries participated in doing it," General Garayev says.

"But Afghanistan needs to be restored. Several generations have known only war, weapons, and death. We have a history with that country, and not only a negative one. The USSR cooperated with Afghanistan since it had a king. There is a chance here to work creatively. Nobody's ever tried that before. We need to step carefully, but we should try," he says.